OBJECTIVES: We sought to assess the disutility associated with diabetes after kidney transplant. METHODS: We enrolled 233 kidney transplant recipients aged 18-74 years (response rate 79%) from a Midwestern hospital outpatient department. Recipients with multiple or multi-organ transplants, those with laboratory evidence that suggests acute cellular damage (Creatinine-Kinase >200 U/L), or a diagnosis of acute renal failure or acute rejection were excluded from the analysis (n=33). Participants HRQOL were evaluated using the Euro-QoL-5 Dimension (EQ-5D), Health Utility Index Mark III (HUI-III), and the Short Form-6D (SF-6D) which was calculated from the generic section (SF-12) of the Kidney Disease Quality of Life 36 (KDQOL-36). We estimated health utilities associated with diabetes using General Linear Modeling after adjusting for demographic, socio-economic, and clinical characteristics. RESULTS: The adjusted Health disutilities associated to diabetes were clinically and statistically significant: EQ-5D (Δ=0.05; p<0.01), HUI-III (Δ=0.09; p<0.01), and SF-6D (Δ=0.04, p<0.01). There was no difference between diabetic patients with good glycemic control (mean serum glucose <126mg/dL in the 3 months prior to enrollment) and patients with poor glycemic control CONCLUSIONS: Among kidney transplant patients between the ages of 18 to 74, non-diabetics have significantly higher HRQOL scores on the EQ-5D, HUI-III, and SF-6D compared to diabetic patients.