OBJECTIVES: Examine knowledge and information seeking behaviors towards blood transfusions among individuals with Chronic Kidney Disease (CKD) currently not on dialysis. METHODS: An online survey was conducted from a nationally representative patient panel in 1Q2011. Respondents were ≥18 years and diagnosed with CKD by a physician. Participants were asked about blood transfusion history, information seeking behaviors, and knowledge about blood transfusion. RESULTS: Of 416 respondents, 59% (n=246) were female; 40% (n=165) were >65 years. 35% (n=144) had stage 4 and 58% (n=240) stage 3 CKD. 54% (n=226) were anemic. 43% (n=179) had received blood transfusion, whereas, 57% (n=237) had no transfusions. Top two sources of information were doctor (93.8%) and Internet (80.5%). Among those previously transfused, 62% received right amount of information, whereas, 34.6% received too little information, and 3.4% reported receiving too much information. More than 80% of transfused indicated they knew the reasons for and benefits of getting a blood transfusion. Less than two-thirds received information about effects, risks, and time it would take, and only 26% knew the costs. Over 60% said that it is extremely important to know right blood type, screening techniques and quality of blood, and risks of infections. Among previously transfused, only half (50%) agreed that they made an informed choice about receiving blood transfusions. Among the previously transfused, 77% agree that they knew the benefits compared with 49% not transfused. Similarly among previously transfused, 69% agreed that they knew the risks of blood transfusion compared to 51% with no transfusion history. CONCLUSIONS: Doctor’s office and Internet are primary sources of information about blood transfusions. Gaps in knowledge exist about benefits, risks, and costs of blood transfusions. A significant number feel that they need more information about blood transfusion to make an informed choice. Providers should consider adopting shared-decision making with their patients.