Fibromyalgia syndrome (FMS) is a multi-symptom disorder primarily characterized by pain. In addition to pain, other symptoms include fatigue, irritable bowel disorder, psychological disturbances like anxiety, depression, cognitive dysfunction etc. The ambiguity of the symptoms and their overlapping nature with other rheumatic disorders poses a huge problem in diagnosis. Meanwhile, patient’s quality of life (QoL) is compromised and deteriorates further. Hence, a thorough exploration in a clinical setting is necessary. Generic instruments lack specificity, while the burgeoning symptom specific instruments present great respondent burden. Validated disease-specific instruments seem to offer the best medium for complete evaluation of FMS patients. OBJECTIVES: To identify available validated disease-specific instruments to enable a comprehensive evaluation of fibromyalgia patients in a clinical setting.The ojective of this review is to provide clinicians and researchers with summarized information on the available instruments and aid them in diagnosis of this disorder. METHODS: A comprehensive literature review from January 1990 to June 2011 was conducted with the combination of following key words fibromyalgia, disease-specific, questionnaires, instruments etc. 58 articles that dealt with  disease-specific instruments in FMS were identified of which 9 articles were included in the final review. RESULTS: Only nine disease-specific instruments were identified in literature which can be classified as: a) Diagnostic tools (2 instruments); b) QoL evaluation tools (6 instruments); and c) Disease knowledge assessment tools (1 instrument). Most instruments possess strong psychometric properties that have been tested in fibromyalgia patients. This review describes the instruments with respect to their psychometric properties, strengths, and limitations. CONCLUSIONS: These instruments can serve as supplementary aids to researchers and clinicians for screening, evaluating, and monitoring FMS patients.