OBJECTIVES: To develop and validate a patient-reported questionnaire to assess the quality of life (QOL) outcomes of Indian breast cancer (BC) patients METHODS: A 27-item questionnaire was developed by literature review, patient interviews (n=6) and expert opinions (n=15). The 24-item questionnaire was finalized. Total 11 domains were considered. The questionnaire was translated to local languages and then it was administered to BC patients (n=30) irrespective staging of cancer and type of therapy. The patients were interviewed and the responses were obtained. Internal consistency, acceptability, content validity, test-retest reliability of the questionnaire was determined and assessment the scores was performed statistically. RESULTS: A 24-item questionnaire was developed as per literature review, patient interviews and expert opinions. Cronbach’s alpha value for the questionnaire was 0.93. Patients understood the questionnaire and found the items to be relevant indicating content validity. The statistical assessment of the scores was not showing the association between scores with age or stage of BC as sample size was less.   CONCLUSIONS: The questionnaire shows good internal consistency, acceptability, content validity and test-retest reliability. It can be used to determine the QOL of BC patients. To our knowledge there is no other questionnaire to determine the QOL outcomes of Indian BC patients. For better results the instrument is needed to be used in larger population.