OBJECTIVES: In Ukraine currently there is no national reimbursement system for pharmaceutical products and major part of pharmaceutical provision, even in hospitals, is covered by out-of-pocket payments of patients. The aim of this study was to define what factors have an impact on drugs prescription process by hospital clinical specialists in Ukraine. METHODS: A brief questionnaire was distributed to conventional sample of 299 doctors with different specializations (surgeons, anesthesiologists, pulmonologists) from four Ukrainian cities (Odessa, Kiev, Dnipropetrovsk, Lviv). Doctors were proposed to rank on10 points’ scale effectiveness, price, efficiency, and number of patients a month he/she is ready to prescribe an antibiotic drug. A dependence between ranking of effectiveness, price, and efficiency of the drug and a number of patients the doctor was ready to prescribe it were analyzed in SPSS using correlation and linear regression analyses. RESULTS: The responders’ missing rate was equal to 1% due to convenient sample selection and face-to-face questionnaire distribution. The difference in answers within doctors of different specializations was not statistically significant. Price of the drug was negatively associated with frequency of drug’s prescription for doctors of all specializations (Beta = -0.171; Sig=0.004). There were no difference is ranking of efficiency and effectiveness (Pearson correlation 0.684; Sig 0.000). CONCLUSIONS: As we conclude from the analysis, practical doctors in Ukraine highly associate efficiency with effectiveness of the medical products. Though, clinical effectiveness has an impact on prescription practice, the price is a determinant.