OBJECTIVES: The original interviewer-administered versions of the Baseline/Transition Dyspnea Indexes (BDI/TDI) were modified by the originator to create self-administered and computerized (SAC) versions. The rationale for the development of the SAC versions was to offer a standardized method for patients to report the impact of activities of daily living on the severity of their breathlessness. The objective of this study is to present the acceptability of the SAC versions of the BDI/TDI to patients with COPD from seven countries including nine different languages [Dutch (The Netherlands), Danish (Denmark) English (Canada, UK), Flemish (Belgium), French (Belgium, Canada), German (Germany), and Spanish (Spain)]. METHODS: A standardized methodology was followed to translate the SAC BDI/TDI (e.g., forward/backward step, review by author). The test on 5 COPD patients in each country was conducted in form of in-depth interviews to evaluate (1) comprehension and (2) acceptability using laptop computers. RESULTS: Overall, most patients liked the SAC versions, and about half preferred it to a interviewer-administered questionnaire. Only four patients had problems using the mouse to click on the right answer for the BDI (e.g., difficulties of coordination, or in using the left button). The items were understood with no difficulties; the main challenging issue was ease in understanding the equivalents of “Baseline” and “Transition”. At first, 42% of the patients, especially in Germany (4/5 patients), Spain and UK (3/5 patients), had difficulties with the instructions to select answers on the TDI using the up-and-down elevator buttons. These difficulties did not persist after the practice question designed to help the patients to become familiar with clicking an “X” (BDI), and using the up-and-down arrows (TDI). CONCLUSIONS: The SAC versions of the BDI/TDI were well accepted by patients from seven different countries. Special attention and supervision should be given to patients not familiar with computer use.