OBJECTIVES: Data availability and decision makers methodology requirements are two important factors influencing transferability of economic studies. Applying qualitative assessment of experts’ opinion and systematic review of published economic studies, we aimed to analyze transferability of economic evaluations in Central and Eastern European (CEE) and former Soviet countries.   METHODS: Firstly, eleven reimbursement experts from eight countries were interviewed on their background and current practice of using economic evaluations, opinion regarding transferability of economic evaluations and importance of individual Welte’s transferability factors. Secondly, we analyzed peer-reviewed English-language economic evaluations of sixteen countries from the region according to different criteria: characteristics, quality (using Drummond’s checklist), use of local data, addressed inputs limitation and results transferability. RESULTS: Economic evaluations are used in CEE countries for informing decision making, while critically considering methodology, quality and study’s reliability. Experts acknowledged limited generalizability of study results both between and within geographic regions. Meanwhile, despite these constraints, facing limited health technology assessment (HTA) capacity experts were still using foreign evidence. At the same time, the usefulness of studies published in CEE and former Soviet countries to inform their decision making is limited because of insufficient transparency in reporting, unaddressed uncertainty, limited insight on inputs and transferability of results. Although local costs, baseline risk and resource use data are required, experts accept evidence originating from health care settings outside CEE and former Soviet countries regarding relative effect and utilities values. CONCLUSIONS: HTA priority setting and transferability assessment of economic evidence are important issue in health care decision making in CEE and former Soviet countries, since HTA research capacity is limited and local evidence is scarce. For this purpose, quality, transparency, and transferability should be addressed explicitly in published economic evaluations originating from CEE and former Soviet countries.