OBJECTIVES Two vaccines protecting against human papillomavirus (HPV) infections are available in Bangladesh for the protection of girls against cervical cancer. These vaccines require cold chain storage and transportation to ensure their maximal efficacy. This storage may represent a large investment depending on the cold chain volume (CCV) needed. The objective of this study was to estimate and compare the total CCV needed for the vaccination of a single cohort of girls in Bangladesh accounting for the difference in packaging for each vaccine. METHODS The total CCV was estimated by multiplying the annual size of the cohort to be vaccinated by the CCV per dose and the number of doses needed per vaccination schedule. Additionally, a buffer factor of 10% as well as a wastage factor (5% for a 1-dose-vial and 10% for a 2-dose-vial) were also accounted for as an assumption. Two vaccines were considered: the AS04-adjuvanted HPV-16/18 vaccine (AS04v) (2-dose-vial) and the HPV-6/11/16/18 vaccine (6/11/16/18V) (1-dose-vial). Dosing scheme (2-dose(2D) for AS04v, 3-dose(3D) for 6/11/16/18V) was according to label in Bangladesh. Alternative 2D for 6/11/16/18V recommended by World Health Organization (WHO) was also used. Their respective CCV per dose were obtained from the WHO Immunization Standards. A cohort size of N=1,591,697 of girls aged 10 eligible for vaccination was calculated from HPVCenter data. RESULTS CCV for AS04v is 4.8cm³ per dose for a 2-dose-vial and for 6/11/16/18V 15 cm³ per dose for a 1-dose-vial. To vaccinate a single cohort of girls the AS04v(2D) would require a total annual CCV capacity of 18.5m³ vs. 82.7m³ for the 6/11/16/18V(3D) or 55.2m³ for 6/11/16/18V(2D). CONCLUSIONS The AS04v was estimated to require between 3.0 and 4.5 less total CCV than the 6/11/16/18V per vaccinated cohort in Bangladesh. This could translate into substantial logistical costs saved in Bangladesh.