OBJECTIVES Impaired Health-Related Quality of Life (HRQoL) of women due to various symptoms of menopause impairments has been given increased importance in the past years. The objective of the present study is to estimate utility values for symptoms relevant for menopause-specific disturbances and to convert them into women’s willingness to give away months of life (time-trade-off) for relief of those symptoms. METHODS A time-trade-off (TTO) model was applied to estimate the utilities of 7 symptoms caused by menopause impairments. A German version of the QualiPause Inventory (QPI) was used for assessing the severity of the symptoms. A quota sample of 478 women, aged 45 to 60 years, was interviewed. Health states were presented to participating women on a mobile computer screen, and they were asked to specify the willingness to give away months/years for the relief of the symptoms, using time-scaled graphic slide controls visible on the computer screen. A total of 45 health states were valued out of a potential of 2,187 defined by the classification system. Logistic regression and Bayes methods were used to estimate the utility values. Utility values were converted into trade-off willingness for life months. Both methods led to almost identical results. RESULTS Willingness to trade-off life months for relief of symptoms ranges between Zero and 132 months of life with a median of 12 months. 25% of the women were willing to trade-off more than 45 months, 5% more than 100 months and 1% even 132 months or more.  Among the more severely rated symptoms are dryness of the vagina, bleedings, and anxiety. CONCLUSIONS Time-Trade-Off techniques can be used to estimate preference values for health states affected by menopausal symptoms and their relief. These values can be used to estimate differential outcomes of hormone replacement therapy.