THE IMPACT OF TREATMENT OF THYREOID DISEASE IN PREGNANT WOMEN TO THE OUTCOME OF GIVING BIRTH
Author(s)
Ferenczy M1, Póhr K1, Lőcsei Z2, Oláh A3, Boncz I4, Karácsony I1, Salamonné Toldy E2
1University of Pécs, Szombathely, Hungary, 2Markusovszky University Teaching Hospital, Szombathely, Hungary, 3University of Pécs, Pécs, Hungary, 4Faculty of Health Sciences, University of Pécs, Pécs, Hungary
OBJECTIVES The most common endocrine clinical symptom is thyroid disease which has impact to pregnant women and fetus. Leading international references about its treatments are well known, there is no relevant experiences in the Hungarian context. Aim of this study is to inspect the thyroid disease and impact of its treatment to outcome of pregnancy. METHODS Survey was carried out at Markusovszky Hospital in Vas County, Hungary. Retrospective study made by data analysis of pregnant patient with thyroid disease, including hormone parameters, medications and obstetric medical history. Set-up was non-random, convenience sampling with 40 women’s data with mean age 33.7± 3.6, between August 2013 – February 2014. Friedmann ANOVA and t-test was applied for analysis with software Statistics for Windows. RESULTS Progresses the gestation period significant reduction of TSH values was observed in hypothyroid patients (p=0,0075). Comparing successive TSH values of the individual patients showed the same significant difference. Significant negative correlation was founded between TSH value and thyroxin dose in group of hypothyroid patients (r= -0,35; p<0,05). Premature birth and other obstetric complications occured more frequently in the thyreotoxical group, especially among older women giving birth. CONCLUSIONS In case of hypothyroid pregnant with increasing dose of thyroxin the TSH levels are well balanced, and obstetric complications did not occur, while in hyperthyroid patients can be reported obstetric complications in addition to proper care.
Conference/Value in Health Info
2014-11, ISPOR Europe 2014, Amsterdam, The Netherlands
Value in Health, Vol. 17, No. 7 (November 2014)
Code
PDB32
Topic
Epidemiology & Public Health
Disease
Diabetes/Endocrine/Metabolic Disorders