BACKGROUND AND OBJECTIVES Economic crisis in Greece has several social implications, as unemployment and poverty have largely increased during the past years. Since the onset of the economic crisis, suicides have marked a significant increase. Therefore, aim of this study is to investigate the relationship between suicides and the economic crisis and certain macroeconomic indices. METHODS Annual suicide rates were obtained from the Hellenic Statistical Authority. Multiple linear regression analysis with Newey-West standard errors was carried out in order to examine the relationship between gender and age specific suicide rates and unemployment, GDP per capita and economic crisis (binary variable). Additionally, several statistical tests were conducted in order to examine the properties and the robustness of the model. RESULTS Unemployment appears as the major factor affecting suicides of men and women above the age of 15. However, gender and age-related differences are being observed. Unemployment is positively associated with the suicides of men aged 15-24, 35-44, 55-64 years. Female suicides are also affected by unemployment, excluding the age groups of 35-44 and 45-54 years old. Interestingly, suicides of women aged between 45-54 and 55-64 were negatively associated with economic crisis. In the total population, unemployment has impact on suicides for 15-24, 35-44, 55-64 age groups, while economic crisis affects suicide rate in the age group of 25-34. In addition, GDP per capita is negatively associated with suicide rates for young men (aged under 24). The same effect is also observed for the young population in general. CONCLUSIONS The current economic turmoil in Greece affects suicides deaths. According to this analysis, unemployment is the main factor that determines age-specific rates and essentially point to the direction where measures should be taken in order to control suicides' incidence and lessen the effect of economic crisis on health.