OBJECTIVES Preventing problems for mothers and babies depends on an operational continuum of care with accessible, high quality care before and during pregnancy, childbirth, and the postnatal period. The objective of this study is to evaluate the quality of life of pregnant women attending antenatal clinics in rural and urban areas of Delta State, Nigeria. METHODS : A descriptive cross sectional study design was used. Six hundred and ninety nine pregnant women attending antenatal clinics in selected hospitals were interviewed using a 31 item pretested, structured questionnaire developed using the World Health Organization Quality of Life (WHOQOL) on Pregnancy assessment brief template. Data assessed include socio-demographics and questions relating to physical, psychological, social and environmental health were used to assess the health related quality of life values in each of the study participants. Data collected were analyzed using the Statistical Package for Social Sciences (SPSS) software version 16.0. The level of statistical significance was set at P<0.0001. RESULTS The mean age of the respondent was 27±5.04. The HRQOL mean scores were highest for the environmental domain (26.39±5.34) and lowest for the social relationship domain (11.43±1.81) . The overall QOL mean scores in the other two domains were: physical health (24.84±3.74), psychological health (21.84±3.03). Significant differences were observed in all domains except social relationship. CONCLUSIONS The health related of life (HRQOL) in pregnant women was found to be lower in those living in the rural areas than their counterparts in the urban areas in all domains except social relationships.