OBJECTIVES Multiple myeloma is common in older adults and its incidence increases after the age of 60 (under the age of 40, it occurs rarely, < 2%). In SK approx. 400 new cases have been diagnosed and in the treatment there is in average 1500 patients. Research aim was to find out the impact of the disease on particular items of Quality of patients´ lives. METHODS Sample: research consisted of  pacienti diagnosed with the disease of multiple myeloma. We distributed 120 questionnaires  and compiled 82 questionnaires (68,33%). There were 36 men (43,90%) and 46 women (56,10%). Their age was between  40 and more. We utilised standardised questionnaire of quality of life, Quality of Life-BREF (WHOQOL-BREF). Its first part included 24 items in four domains (physical health, psychological health, social relationships, and environment) and two items of overall evaluation. Numerical scales were signed in the answers in the following way: the least auspicious answer had the smallest value and the most auspicious answer had the biggest numerical value (range 1 – 5). The results of respondents were compared to population norms of the WHOQOL-BREF domains. RESULTS In majority of items, the answers of the respondents do not differ very much in comparison with the average score of WHOQOL-BREF. Two items mostly differ from the average score most: domain of physical health – pain, where the average of 2.5 lowered in comparison to population norm of 4.03. The domain psychological health – negative emotions: where the average of 2.00 was lower in comparison to the population norm of 3.47. CONCLUSIONS Prompt diagnostics of multiple myeloma significantly increases the possibility of the treatment to be successful. It also prolongs and improves quality of patient life. Research finding points out the reality that MM does not have the same impact on all domains of quality of life.