OBJECTIVES: To evaluate the management of Chronic Thromboembolic Pulmonary Hypertension (CTEPH) in a referral hospital by assessing clinical variables, patient-reported outcomes and caregivers’ burden. METHODS: An observational, retrospective study was conducted. All patients (aged >18 years) attending the specialised unit on CTEPH at the 12 de Octubre Hospital (Spain), between January 2010 and November 2012, were offered to participate. Clinical variables were recorded at the clinical session for treatment decision (Pulmonary endarterectomy –PEA- if operability was confirmed or medication therapy –MT- if inoperable), and after one year. Outcomes considered: The New York Heart Association Functional Class (FC), 6-Minute Walking Distance, pulmonary arterial pressure, pulmonary vascular resistance and pro-brain natriuretic peptide. Participants completed the EQ-5D and caregivers’ fulfilled the Zarit Burden Interview. Differences between groups were studied (Chi-squared, Mann-Whitney U and ANCOVA). RESULTS: A total of 64 CTEPH cases (57.8% males) were included. Mean (SD) age at diagnosis was 55.8 (14.9) and 67.2% had an III-IV FC at diagnosis. At the moment of treatment prescription, differences in clinical variables were not found (all p>0.4) between PEA (n=35-54.7%-) and MT groups (n=29-45.3%-). After 12 months, 8 patients died (2 in PEA group and 6 in MT). Among survivors, FC was significantly better in PEA group (93.9% improved at least one level).  Regarding EQ-5D, patients undergoing PEA showed significant higher utilities (0.83-0.17- vs. 0.53-0.31-p=0.007) and VAS values (80.22-14.24- vs. 49.47-20.68-p<0.001). Furthermore, mean VAS values in PEA group were comparable to general population (adjusted by sex and age). Finally, formal care was needed by just 4.8% of patients in PEA versus 33.3% in MT. Reported caregivers’ burden were relatively low in both groups (p=0.87). CONCLUSIONS: The positive outcomes obtained, especially in those patients undergoing PEA, suggest the experienced management of CTEPH by this referral hospital and highlights the importance of detecting candidates for PEA.