OBJECTIVES In Ghana it is estimated that 1.7% of HIV infections occur in young people aged 15-24. Despite this the representation of young people in our clinics is small. Adherence to treatment, appointment keeping and knowledge of HIV status remain a challenge. Disclosure has been shown to confer the following benefits. The study sought to assess the knowledge of HIV status of adolescents and young adults. METHODS A baseline study was conducted to ascertain if adolescents and young adults knew their HIV status and also determine their knowledge on HIV in general with 34 participants. An adolescent club was established to engage with young people, provide better tailored care and support and to solve their peculiar challenges.  Self-administered questionnaires were used and data were analyzed with SPSS version 16. RESULTS The mean age was 16.9 ± SD 2.5 and 21(62%) were mainly females and in school. Four were in primary school, 14 in junior secondary school, 12 in senior secondary and another 4 in tertiary institutions. Most (85%) were aware that young people their age could fall sick, . 91% had heard of HIV, 70% knew someone with HIV and 45 % thought that adolescents were not at risk of HIV. Eighteen (52.9%) knew their HIV status,17 (50%) were on antiretroviral and 32% of these admitted to missing Anti-Retroviral (ARVs) dose. CONCLUSIONS Disclosure of HIV status to adolescents and young people is dependent on a complex mix of factors and most practitioners recommend an age and developmentally appropriate disclosure. The knowledge and awareness of HIV was 91%.  There is also the need to support care givers to disclose HIV status and to support young people to adhere to ARVs for better outcomes. Keywords: Knowledge; Disclosure Adolescents/Young Adults; HIV, Ghana.