OBJECTIVES The health care system of Ukraine is being transformed according to the modern world format. More and more doctors are aware of the need for the use of technologies based on evidence-based medicine, particularly in the management of hepatitis C. METHODS In 2013 the multidisciplinary working group involving professionals and patients developed an adapted clinical guideline, based on HTAs and strategies of evidence-based medicine on the treatment of hepatitis C, and unified clinical protocol “Viral hepatitis C”. RESULTS The differences in the treatment of hepatitis C in Ukraine compared to the best international practice were revealed and considered while developing medical and technological documents for health care in hepatitis C. Doctors and the public were informed of modern evidence-based technologies concerning management of the hepatitis C. As a result, the multidisciplinary working group adapted these documents of best methodological quality. Introduction of these documents reorients doctors on a modern approach to the assessment of scientific medical information. The unified clinical protocol contains provisions for minimum acceptable quality of primary and specialized medical care and the algorithms of patient’s identification. CONCLUSIONS Provision of changes in the current medical practice is associated with the introduction of modern medical technologies based on evidence-based medicine. Ukraine has implemented the algorithm for the use of best practice: a multidisciplinary working group adapts clinical guidelines based on evidence → creates unified clinical protocols → each health institution develops local protocols, taking into account the resources of a health facility and interaction of these institutions.