OBJECTIVES: To assess medication adherence to DMARD in patients with Rheumatoid Arthritis using CQR and MARS tools, identification of factors affecting adherence and its effect on quality of life.   METHODS: A randomly selected sample of 110 adult patients with RA on DMARDs admitted to hospital were asked about their medication adherence, through self-report questionnaire [CQR and MARS] and quality of life was assessed by HAQ ( Health Assessment Questionnaire). Additionally, various factors affecting adherence were identified.   RESULTS: According to the tools used, 86.4% (CQR), 74.29% (MARS -mean cut point) and 95.45% (MARS -prior study cut point) of patients showed adherence towards DMARD. Better adherence was seen in patients with primary education (COR- 94%) or secondary education (MARS -83%). Patients who suffered from RA for more than 2yrs showed better adherence (CQR- 93%) compared to those with recent disease (<2yrs) (CQR- 89%). Non adherence was seen in patients having co-morbidities compared to patients with only RA (CQR- 91% vs 94%; MARS- 62% vs 82%). Mean HAQ of adherent patients was better (2.83±1.05) than non-adherent patients (3.23 ± 0.74). Adherent patients showed moderately active disease state (Mean DAS – 5.96 ± 1.67) whereas, non-adherent patients showed highly active disease state (Mean DAS – 6.70 ± 0.84).       CONCLUSIONS: Patient reported questionnaires showed disease duration of less of 2yrs, and patients with co-morbidities lead to Non-adherence which worsened disease activity which lead to decreased quality of life.