OBJECTIVES To compare a newly developed condition-specific utility index (CSUI), the Pressure Ulcer Quality of Life Utility Index (PUQoL-UI) with generic and directly elicited TTO values.  METHODS The PUQoL-UI was completed by a group of patients (n=100) in England with pressure ulcers (PUs) along with the EQ-5D and own health TTO. The discriminatory power of the utility measures was assessed across PU grade and health and PU severity ratings. Multivariate regression was conducted to explore determinants of utility values. RESULTS The mean sample age was 77.2 years (range 22.7-101.7), 49% were female and 50% wheelchair users. Mean (SDs) utility for superficial PUs (grades 1-2) were 0.72 (0.17), 0.70 (0.35) and 0.24 (0.16) and for severe PUs (grades 3-4) 0.67 (0.17), 0.65 (0.35) and 0.15 (0.38) for the PUQoL-UI, TTO and EQ-5D, respectively. Mean (SDs) utility by self-reported PU severity was: [Mild] 0.78 (0.16), 0.66 (0.35), 0.29 (0.36); [Moderate] 0.72 (0.17), 0.63 (0.38), 0.25 (0.34); [Severe] 0.58 (0.17), 0.70 (0.33), 0.04 (0.40) for the PUQoL-UI, TTO and EQ-5D, respectively. Regression analyses indicated both EQ-5D and PUQoL-UI values were explained by perceived severity and general health ratings but not demographics or PU grade. Duration and body part affected were additional significant explanatory factors of the EQ-5D while wheelchair use approached significance.  CONCLUSIONS Values were much lower for the EQ-5D than the other assessments which may be partly explained by the range in EQ-5D and partly due to background mobility issues being captured. The PUQoL-UI appears to have good discriminatory power and is recommended for use in trials of PU interventions. The utilities presented here will be useful for decision-analytic models that incorporate PU impact. Probabilistic sensitivity analyses including the PUQoL-UI will likely generate lower levels of uncertainty than the EQ-5D due to the smaller SDs for health states.