OBJECTIVES: Comprehensive economic costs of multiple sclerosis (MS) according to EDSS states can only be assessed by evaluating MS management in real clinical practice. The objective of this cross-sectional study was to measure the resource utilisation and the costs associated with health-care management of MS in Slovakia and to provide a basis for cost-effectiveness evaluations.  METHODS: Descriptive epidemiological data of 2,552 MS patients from 27 MS-centers across Slovakia were collected electronically and analyzed. In 152 selected patients followed up in 2011-2012 in 34 MS centers, all types of health-care services and costs were analyzed. These patients were randomly included in the study. Continuous variables were calculated using standard descriptive statistical methods.  RESULTS: