OBJECTIVES Dengue infection is a major cause of disease in tropical areas with an estimated 50 million infections occurring each year and more than 2.5 billion people being at risk of infections. The main objective of this study was to investigate relation between white blood cells and platelets during recovery phase in dengue hemorrhagic fever METHODS A retrospective multi-center study was conducted on 1000 seropositive cases of dengue fever RESULTS More prevalence has been observed in male 880 (88%) as compared to female 120 (12%). A rapid fall in white blood cells count (WBC) was observed in initial CBC reports at start of disease then in platelet count. During recovery phase WBC count increased first followed by platelets count production after 3-4 days. Among 1000 confirmed dengue fever patients 812 were considered dengue hemorrhagic fever cases on the basis of clinical finding. In most of these cases (n=783; 96.47%), directly proportional relation was observed between WBC and platelets count CONCLUSIONS It is wrongly perceived in community that dengue virus infection is still progressing when platelets count is below normal even the white blood cells counts is getting better during recovery phase. White blood cells production during recovery phase is a good indicator about recovery of disease rather than focused on platelets counts production.