OBJECTIVES Management of symptoms and illness for post traumatic stress disorder (PTSD) requires effective and prolonged psychiatric support. Re-experiencing traumatic memories and events via virtual reality exposure therapy (VRET) can lead to reduction of illness and symptoms associated with PTSD. This systematic literature review aims to demonstrate the value of VRET in the management of illness and symptoms associated with PTSD. METHODS Studies published in the English language for PTSD and VRET were retrieved from Embase, PubMed, and Cochrane databases using relevant search strategies. Two researchers are independently reviewing studies as per the Cochrane methodology for systematic literature reviews. We considered VRET as a tool to deliver therapy programs via a virtual platform to patients suffering from PTSD. The main outcome will be improvement in symptoms such as anxiety, various phobias and depression developed as a result of PTSD. Outcomes will be measured as change in baseline characteristics in patients using VRET, by using questionnaires specific to the symptoms being measured such as Beck’s Anxiety Inventory, Beck’s Depression inventory-II (BDI-II), Clinician-Administered PTSD Scale (CAPS), and patient reported outcomes. RESULTS In total, 2574 potentially relevant studies were retrieved from the databases and are being screened for inclusion in the review. The detailed results from the systematic review will be presented in the poster. CONCLUSIONS The evidence from this systematic literature review will hopefully suggest the role of VRET as a promising new tool for managing PTSD from a psychotherapeutic perspective.