OBJECTIVES: TBE is a serious central nervous system disease, which may lead to permanent neurological sequelae or even death. TBE is becoming a high burden in many parts of Europe, Asian Russia, Siberia, Asian former USSR and Far East. The burden is usually expressed by only the incidence or death. DALYs give a composite assessment of TBEʼ s burden while only the incidence or deaths does not really indicate the real impact on burden. The purpose of the present study is to estimate the burdens from the population- and individual perspectives for TBE in Slovenia, measured in DALYs and evaluate the possibilities of reducing this burden. METHODS: The burden of TBE in Slovenia is estimated by using the updated DALYs' methodology first introduced by Murray and co-workers in the Global Burden of Disease (GBD) project. Adjustment to correct for under-reporting and under-ascertainment is applied. Calculations were based on the health outcomes of the natural course of TBE. RESULTS: From the population perspective DALYs amount to 3,450 while from the individual perspective they amount to 3.1. The neurological sequelae have the largest impact on the overall DALYs measurement for TBE. CONCLUSIONS: Rising awareness and increasing vaccination coverage for TBE is proposed for the whole population to reduce the burden and provide health benefits to the population as a whole in Slovenia.