OBJECTIVES MediGuide technology is designed to monitor the position of diagnostic and therapeutic catheters equipped with a sensor MediGuide and navigation in vascular or cardiac intervention in the environment of electro-physiological laboratory. MediGuide compared to conventional technology, offers the 3D display on the live fluoroscopy or recorded background, radiation burden reduction, fluoroscopy time and total time performance. The aim of this thesis is to analyze the clinical and cost effectiveness of new technologies MediGuide in the Czech Republic. Results of the analysis are being compared to the studies of the German Cardiac where technology is positively evaluated. METHODS The evaluation method is cost-effectiveness analysis, which compares technology system MediGuide to a comparator angiography Siemens Artis Zee. Value of the effect was determined by TOPSIS in which they were entered weight values obtained by Saaty method of pair comparison by group of experts. The sum of direct costs includes costs associated with the operation of both technologies. Calculated values of costs and effects were achieved in incremental ICER assessment ratio, fixing the amount of costs per unit of effect. RESULTS More appreciated criteria in Saaty method were: safety and effectiveness of the technology. The fundamental values of the following criteria in this method were used: radiation burden, which in the Czech Republic reached values using conventional technology 575±511μGy.m2 and in Germany 14,453±7,403μGy.m2, fluoroscopy time values for Czech Republic 7.5±4.5min; Germany 34±9min and total time performance of Czech Republic 148±91 min; Germany 157±51min.  The cost of power at the treatment of 100 patients was in the first year to CZK 181,711; MediGuide under the same conditions CZK 276,765.  CONCLUSIONS Manufacturer of MediGuide values technology as an effective, safe and value-added reduce the radiation burden of the patient, fluoroscopy time and shorten the overall time performance.