OBJECTIVES: Gaining reimbursement is a complex process that involves generating the right evidence and communicating it successfully to stakeholders. To ensure alignment of the value story across countries and help affiliates in their local submissions, headquarters (HQ) develop the global value dossier (GVD). We have investigated whether the current GVD meets HQ and local affiliates (LAF) expectations. METHODS: Pharma HEOR and market access professionals from HQ and LAF were invited to participate in telephone interviews to assess their views on current use and utility of the GVD. Results were analyzed to identify differences and alignments between HQ and LAF. RESULTS: CONCLUSIONS: HQ and LAF expectations differ particularly on how soon the GVD should be made available, the involvement of affiliates during its development and the applicability of the GVD contents to local submissions. How to address these discrepancies to ensure alignment will be discussed.