OBJECTIVES: To assess the burden of LN in comparison to SLE patients without Nephritis (Non-LN) in routine clinical practices in EU. METHODS: A multi-center medical chart-review of adult (16-89yrs) SLE patients was conducted among rheumatologists and internal medicine physicians in UK/France/Germany/Italy/Spain (5EU). Physicians were recruited from a geographically representative sample in each country. Approx. 5 consecutive eligible persistent active or relapse remitting SLE patients currently managed as part of usual care were identified. Physicians abstracted de-identified patient data on disease characteristics, lab values and treatment patterns. LN and Non-LN cohorts were compared using descriptive statistics. RESULTS: CONCLUSIONS: LN cohorts had higher clinical and humanistic burden in 5EU in comparison to their non-LN SLE counterparts. Factors influencing the observed burden, including the therapeutic strategies used in these geographies warrant further investigation to manage SLE, and LN in particular, optimally.