OBJECTIVES MyCognition has already demonstrated that its adaptive video game programmes are able to enhance cognitive health in healthy volunteers (FENS, July 2014). It is now using the same technology to assess and train cognitive health in psychiatric and neurological patient populations that have cognitive impairment. METHODS In both the psychiatric and neurological patient population it is planned that all with have their cognitive health assessed prior to commencement of the study to provide a baseline score. This will be for the 5 key cognitive domains (attention, psychomotor speed, episodic memory, working memory and executive functioning). All will then be randomised to either active or control group. The active group comprises adaptive video training of at least one hour per week over a 12-week period on top of standard care. The control group receives standard care alone. All the subjects will have their cognitive health assessed at 0, 4, 8 and 12 weeks. They will also have their condition assessed via a specific scale, e.g., PANS for Schizophrenia, UPDRS for Parkinson’s. The results will be calculated as change from baseline for both groups at 4, 8 and 12 weeks. RESULTS In previous tests in healthy volunteers a significant improvement in cognitive health was seen after 4 weeks of training. By 8 weeks it was possible to see a dose response to the duration of training, with longer training showing a greater effect. CONCLUSIONS Detrimental cognitive health is seen in many neuropsychiatric conditions. To date, drug therapies have had a poor impact on cognitive disorders. This adaptive video training programme presents a potential therapeutic intervention that is safe and effective. The online assessment can be used to profile at risk subjects and the training could be used to prevent as well as treat cognitive decline.