OBJECTIVES: The patient-centered medical home has been touted as a way to improve patient care and reduce overall healthcare costs.  Pharmacists are qualified to provide many of the services that are core to the medical home concept as part of the physician-directed team; however, the pharmacist’s role in the medical home has received little attention. METHODS: Medical record review was performed on all patients referred to the pharmacist from 7/1/2009 to 12/1/2010 within a community-based, medical home, primary care practice.  Patients referred included those non-compliant to prior physician recommendations for lifestyle modifications and/or those not achieving therapeutic goals. Pharmacist interventions included disease state education, therapeutic lifestyle modification and medication counseling, and recommendations for therapy optimization.  Primary analyses examined pre/post changes in the subset of patients with diabetes. Outcomes assessed were changes in hemoglobin A1c (HbA1c), lipid fractions, body mass index (BMI), weight, and goal attainment for HbA1c and low-density lipoprotein cholesterol (LDL-C), utilizing paired t-tests, Wilcoxon signed-rank and McNemar’s tests as appropriate.  RESULTS: One hundred-seven patients were referred to the pharmacist, 49 with diabetes.  Diabetes patients had a mean age of 57±9 years; 53% were male.  HbA1c values decreased from 8.7% to 7.4% (Δ=-1.3%; 95% CI= -0.5% to -2.1%; p=0.003).  The percentage of patients achieving HbA1c levels below 8% rose from 50% to 75% (p=0.021) and below 7% rose from 28% to 47%, although this was not statistically significant (p=0.109). Statistically significant decreases were observed in diastolic blood pressure, LDL-C, total cholesterol, triglycerides, BMI and weight.  The percentage of patients achieving LDL-C levels <100mg/dL increased from 30% to 74% (p=0.002). CONCLUSIONS: Pharmacist involvement in this community based medical home was associated with positive improvements in clinical markers for these diabetic patients.  These pilot study results support the inclusion of pharmacists as healthcare team members in future medical home demonstration projects.