The execution and management of Health Services Research projects can be an onerous task.  Often there is no centralized body of knowledge within an organization around process and requirements.  This leads to long execution timelines, difficulties with vendors and ultimately reduced productivity. The Collaborative Science Center of Excellence (CSCoE) was established in 2008 at Bristol-Myers Squibb (BMS).  This group  manages the global operations of a wide variety of programs, a portion of which includes worldwide investigator sponsored research, non-clinical research, expanded access, and risk evaluation and mitigation programs.   Beginning June 2009, operational management of the entire US Health Economics and Outcomes Research (HEOR) book of work was moved from the OR Scientists into the CSCoE.  This included administration, contract execution, master service agreement negotiation, financial management, protocol writing, AMCP dossier updates, and invoice tracking and payment. Within the first year over 90 projects were migrated into the CSCoE.  Benefits the Health Services Research group realized included: 1. A consolidated 2010 and planned 2011 book of work; 2. A reportable repository of project information; 3. HEOR protocol and AMCP dossier improvement through standardization of in-house scientific writing; 4. Expedited contract execution; 5. Innovative cost-sharing; 6. Tiered and batched review of contracts reduced corporate legal hours; 7. Rapid response to organizational queries. Centralized process management unlocked latent value by allowing OR Scientists to focus on value-added activities, increased organizational transparency and agility, and moved operations to a lower cost environment.