OBJECTIVES: Evaluate the impact on cardiovascular risk control and its determinants in patients enrolled in the Disease Management (DM) Program “De Todo Corazón”. METHODS: The objective the DM program is to modify cardiovascular risk (CVR) classified according to Adult Treatment Panel III (ATPIII) methodology, the program includes direct pharmacological intervention, integrated with promotion and prevention activities. This program began in 2004 and 27,596 patients corresponding to a dynamic cohort have received its benefits from it up to December 2009.   The effectiveness of the program was assessed through the analysis of trends in the CVR marker variables and goals accomplishments.  The study population corresponds to participating subjects since 2004 who received continuous annual follow-up visits until 2009.  The trend analysis of the different risk factors over time was performed, as well as the estimate of the annual CVR using ATPIII categories (High, moderate and lower risk). RESULTS: 3,870 subjects were included in the assessment with a mean age of 62 years (SD=11.52) and the majority of subjects are women (73%). The results showed a reduction of 30% in smoking. In addition, over the past 5 years, blood pressure (BP) diminished consistently through risk groups (mean reduction of 14 mmHg); LDL cholesterol levels were reduced within high and moderate risk groups (mean reduction of 25 mg/dl) and the speed of kidney damage progression decreased. Complementary analyses with an extended cohort containing over 8,000 patients exhibited similar results. CONCLUSIONS: Cardiovascular Risk DM Program “De Todo Corazón” showed a meaningful impact to modify risk factors in Colombian patients such as smoking, BP, lipid profile and kidney risk. The results of a wider cohort supported that observed positive outcomes trends were generated by this program.