OBJECTIVES: To assess health status, treatment patterns and quality of life in patients with hereditary coagulopathies in Kazakhstan. METHODS: Postal and telephone health survey. Questionnaires were distributed in May - August 2009. The questionnaire contained questions on clotting factor level and presence of antibodies to it, number of bleeding in last month, number of injections of clotting factors per month, names of used medications, ways of receiving medications, number of ambulance calls and hospitalizations, and the way of administration of medicines (self-administration of administration at a ambulatory/hospital). The patients’ education level and employment data was collected. Health-related quality of life was assessed with self-administrated validated version of Russian version of Euroqol-5D questionnaire. Comparison was made with health-related quality of life of Russian patients data (P.Vorobeyv et. al., 2008, data of 1003 patients was used in analyses). RESULTS: 626 completed questionnaires were received by September, 2009. Health-related quality of life was assessed for patients older than 11 years (n = 514). More than half of patients reported problems within each of EQ-5D dimensions of health. Thus 63.9% of patients reported of problems (moderate and severe) with mobility (63.9% of Russian patients, p>0.05); 65.2% of patients informed of difficulties with self-care (35.5% of Russian patients, p<0.05); 70.1% of patients had difficulties with usual activity (61.9% of Russian patients, p<0.05); 74% of patients reported of presence of pain or discomfort (78.4% of Russian patients, p>0.05); 27.3% of patients had an anxiety or depression (54.2% of Russian patients, p<0.05). The average value of quality of life evaluated with visual-analog scale (VAS) was 0.53 (SD 0.18), median - 50. CONCLUSIONS: Results of the study shown high rate of problems with mobility, usual activity and high rate of pain/discomfort and low rate of problem with anxiety/depression.