OBJECTIVES: Research shows a significant association between low bone mineral density (BMD) and persons receiving antidepressant medication, with levels of BMD loss varying with the type of pharmacological agent used. This study compared the BMD of depressed patients on different groups of antidepressants. METHODS:   One hundred forty male and female depressed subjects between the ages of 25 – 70 years were recruited from the psychiatric clinics in Penang General Hospital and Penang Adventist Hospital. The groups of antidepressant medication included selective serotonin reuptake inhibitors (SSRI), tricyclic antidepressants (TCA) and other types of antidepressants (OTA). BMD was ascertained by measuring the quantitative ultrasound derivative Z-score from the calcaneal bone of the heel using an Ultrasound bone densitometer by Furuno Electric.  RESULTS: ANOVA found no significant differences in mean BMD across the different groups of antidepressants (p=0.055).  CONCLUSIONS: This study finds no association between BMD loss and the type of antidepressant employed in a depressed Malaysian population.