OBJECTIVES: Atrial fibrillation (AF) may manifest with comorbidities. We examined the prevalence of comorbidities and general medication use among AF patients in order to assess total disease burden METHODS: Data were obtained from the 2009 National Health and Wellness Survey (N=75,000), an annual cross-sectional Internet-based survey of adults in the United States. In addition to demographics and medication use, patients with AF also reported on their comorbid conditions. Using demographic and patient characteristics, a CHADS2 score (an index of stroke risk) was calculated for each patient. RESULTS: A total of 1297 patients reported a diagnosis of AF. The mean age was 64.9 years (SD 12.2), and 65% were male. In addition to AF, these patients reported comorbidities in various organ systems, including 90% with a cardiovascular condition, 62% with a urological condition, 42% with a respiratory condition, and 41% with a gastrointestinal condition. Specific comorbid conditions reported in this AF patient population included hypertension in 72% of patients, history of myocardial infarction in 21% of patients, heartburn/gastroesophageal reflux disease in 29% of patients, and allergies/hay fever in 29% of patients. The mean Charlson Comorbidity Index score was 1.53 for all patients. Almost half of patients (46%) had a CHADS2 score of ≥2. The percentage of patients reporting current medication use included: 71% for AF, 64% for hypertension, 50% for hyperlipidemia, 29% for arrhythmia, 24% for diabetes, and 26% for gastrointestinal medications. Overall, 43% of patients with AF were using an anticoagulant medication. CONCLUSIONS: This self-reported national survey identified AF patients as having a high comorbidity burden, with conditions affecting a variety of organ systems. Medications used to treat a variety of conditions are also highly prevalent and should be taken into account in managing patients with AF.