OBJECTIVES: PROMIS measures have been tested in community populations, but have been much less studied in clinic patient populations.  We examined the correlations between the PROMIS Sleep Disturbance, Fatigue, and Depression measures and scale scores on the SF-36 among patients being seen in clinic prior to surgery. METHODS: A series of patients being seen for pre-surgical consultation were recruited from Henry Ford Hospital surgery outpatient clinic.   They completed a set of PROMIS CAT measures (Sleep Disturbance, Fatigue, Depression) using the Assessment Center, and also completed the SF-36 survey as part of the regular clinical care process.   SF-36 dimensions were scored on a 0-100 scale.   Spearman correlation coefficients were calculated as the primary measure of agreement between the SF-36 and the PROMIS CAT measurements.   RESULTS: There was reasonable variability on all three PROMIS measures.   The three PROMIS measures were significantly correlated with each other (r = 0.38 to 0.57).  All SF-36 domain scores were highly correlated with the PROMIS Sleep and Fatigue CAT measures, except for the SF-36 Role-Emotional scale.  Several SF-36 domain scores were highly correlated with the PROMIS Depression CAT measure.  The correlation coefficients between the PROMIS Depression scale and the  SF-36 domains with which it was significantly correlated were essentially equivalent.  The PROMIS Fatigue and Sleep Disturbance measures both had a higher degree of correlation with the SF-36 Vitality scale than with other SF-36 domain scales. CONCLUSIONS: In a population of clinic patients being seen prior to surgery, scores on three PROMIS CAT measures were highly correlated with scores on most domain scales of the SF-36, providing evidence for the validity of the PROMIS measures in this setting.  The consistent level of correlation across various measures suggested that all may be reflecting a general sense of good versus poor health in this cohort of pre-surgical patients.