OBJECTIVES: The objective of the Italian Workshop in Pharmacoeconomics (WEF) is to validate an innovative experience that aims at being recognized by Institutions as a national and independent HTA assessor, thus supporting both national and regional healthcare decision-makers. This experience consists of a multi-stakeholder  working group that, in the field of new technologies proposed for critical clinical areas,  discusses and develops guide-lines and decision rules and comparatively examines local data. METHODS: The working method consists of a series of meetings (4 per year) of a scientific board (composed by high-profile experts covering all HTA domains) that carries out a nationwide analysis of the topic  under examination  and focuses on the main clinical, economic, organizational, social, and ethical aspects. Questionnaire-based surveys and Delphi panel are the main operational tools. WEF  adopts standard HTA procedures according to the EUnetHTA Core Model. To avoid any conflict of interests, no fee is paid to any member.  RESULTS: Since 2011,  three HTA reports have been completed focusing in 2011-2012 on hepatology (HCV/HBV screening and treatments)  and extending in 2013 to other topics including hepatocellular carcinoma and inflammatory bowel diseases; HIV is coming up next year. Along with 4 publications in international journals (mean impact factor 5.73), there have been auditions at the Italian Drug Agency (AIFA) and at the Healthcare Commission in Parliament that have facilitated the approval of new HCV drugs. Furthermore, delays in approvals by regional formularies have been reduced by about 65% (from 212 days after national marketing authorization to 74 days; Farmindustria data). CONCLUSIONS: This new multidisciplinary and multistakeholder approach proved to be well-accepted,  and the “WEF method” is already recognized as a milestone in the Italian HTA landscape, by both Institutions (e.g. AIFA and Italian MoH) and Scientific Societies, thus helping payers in making rational decisions based on HTA methods.