OBJECTIVES: The Cervantes scale is a specific health-related-quality-of-life (HRQoL) questionnaire developed in Spanish women through and beyond menopause. The original scale contains 31-items and it is time-consuming in the routine medical practice. The aim of this work was to reduce the 31-item scale and to produce an abridged version with the same dimensional structure and similar psychometric properties. METHODS: A representative sample of 563 women [mean age 60 years old (SD=6.7, Min=46, Max=82)] extracted from the Ginerisk study was used. The Ginerisk was an epidemiological, cross-sectional study carried out in 4,157 Spanish post-menopausal women attending out-patient clinics of Gynecology throughout Spain in year 2011. Item analysis, internal consistency reliability, item-total and item-domain correlations and item correlation with the generic Spanish version of the MOS-SF12v2 questionnaire dimensions were initially studied. Dimensional Confirmatory Factor Analysis (CFA) and Full-model CFA were used to check structure stability. A 3-fold cross-validation method was used to obtain stable estimates, by means of multi-group analysis. RESULTS: The scale was reduced to a 14-items version: The Cervantes-SF, containing four main dimensions: Menopause and health, Mental health, Sexuality, and Couple Relationship, being the first dimension composed by 3 sub-dimensions: vasomotor symptoms, health, and Aging. Goodness-of-fit statistics were better than those of the extended version (chi-square/df=2.130, AGFI=0.859, PCFI=0.919, RMSEA=0.044). Internal consistency was good (Cronbach’s alpha=0.830) but slightly lower than that of the original scale. Correlations between extended and reduced subscales was high and significant in all cases (p<0.001), ranging from r=0.857 for Aging to r=0.971 for Vasomotor symptoms. CONCLUSIONS: The Cervantes scale may be reduced to an abridged version of 14-item (Cervantes-SF) which maintains the original dimensional structure and psychometric properties. This version extends 45% of the original length, being faster to apply and making it specially suitable for routine medical practice.