OBJECTIVES: Primary objective of the Percepolis study was to look at patient’s perception regarding their Erythropoiesis Stimulating Agents (ESA) treatment of anemia in chronic kidney disease. Many discussions arose at the set-up of the study regarding the best collection method of PROs as target population was old. The following factors helped to make a decision towards ePRO: - Clinical data were collected using an eCRF and previous experience of studies using PROs showed it was difficult to mix method of collecting data, - PRO was the primary endpoint of this study and needed to be carefully monitored, - Most elderly people use new technologies (cellular phone, PC), - Twenty questionnaires needed to be equally distributed. METHODS: This is a 6-month multicenter prospective Non-Interventional Study (NIS). Patients had to complete questionnaires at baseline and around 6-month in order to analyze the importance they gave to their ESA treatment characteristics. Technology used was the Tablet PC Samsung Galaxy Tab and specific interface was developed on the Operating System (O.S.) Android to maximize ease of use of the device for patients and investigators. For example, patients only had to select an answer on the screen to display the next question using the tactile functionnalities of the device. When connecting to the electronic data capture system, O.S. was detected in order to fit the screen’s display of the HTML pages. RESULTS: 789 patients were included, 93% patients answered at least one questionnaire at baseline, 87% after 6 months of treatment. Mean age of the study population was 73 years old (± 13 years). Most PROs (95%) were answered using the Tablet PC. CONCLUSIONS: ePROs can be used in elderly population as long as tools are adequately developed to simplify use of devices. ePROs also allowed following online study recruitment and questionnaires data entry.