OBJECTIVES: To undertake a comparative analysis of 2 methodologies of intensive treatment (IT) , precisely: IT without NS and IT taking into account NS handling. METHODS: Pharmacoeconomic analysis “budget impact” was provided. Only direct costs were taken into account: expenses for drug therapy, hospitalization (intensive care unit and medical division) and late complications (pneumonia, sepsis, catheter and wound infection) treatment. Effectiveness data was taken from Russian clinical trial: Popov T.S., Shestopalov A.E., Tsvetkov D.S., Nechaev D.S., Kuz’min M.A. Nutrition Day in intensive care units of the Russian Federation. National association of parenteral and enteral nutrition – Moscow (Russia), 2011. Four types of NS were compared: IT without NS; IT + enteral nutrition (EN); IT + parenteral nutrition (PN) and IT + combined nutrition (CN). RESULTS: When carrying out comparative pharmacoeconomic study all calculations were made for 3 groups of patients depending on their health condition: lightly-severe, moderately severe and severe. According to the results of calculations transfer of patients from IT without NS to IT carrying out NS leads to reduction of total expenses, therefore economy of money for the state. Independent from patient health condition – the greatest economy of money arises when EN is used during IT. Further on degree of expressiveness of positive economic effect there is PN and the least NS economic type is CN. CONCLUSIONS: The results received during the study were analyzed and the rating of NS types, which were taking part in the research, from the point of view of their clinical efficiency and economic effectiveness for the state budget, was made.