OBJECTIVES: In the RAPID1 randomized controlled trial (RCT; NCT00152386), certolizumab pegol (CZP) every 2 weeks (Q2W) plus MTX provided rapid improvements in clinical measures, and workplace and household productivity over 52 weeks (wks) in patients (pts) with active rheumatoid arthritis (RA). We report the long-term effect of CZP+MTX Q2W on workplace and household productivity and social participation in RA pts from the RAPID1 open-label extension (OLE; NCT00175877).   METHODS: RAPID1 52-wk Completers and Wk16 Withdrawers were eligible for treatment in OLE with CZP 400mg Q2W +MTX, reduced per study protocol to 200mg Q2W +MTX after ≥6 months in OLE. Workplace and household productivity were assessed through the validated RA-specific Work Productivity Survey (WPS-RA). WPS-RA responses (observed cases) are summarized for CZP RCT Completers who enrolled in OLE and completed WPS-RA at OLE completion/withdrawal visit (C/W). RESULTS: Of CZP Completers who enrolled in OLE (N=508), 388 remained at Wk208 (4yrs) and a subset of 290 completed WPS-RA at OLE C/W (after minimum 4.3 and maximum 6.2 years CZP treatment from RCT baseline [BL]). Of these pts at RCT BL (N=267), 49% were employed outside the home, 21% were RA work-disabled, 14% were homemakers and 13% were retired. Employed pts reported long-term reductions in absenteeism [mean BL:3.7 (N=131), C/W:0.1 (N=129)], number of days with decreased productivity (presenteeism) (mean BL:7.8, C/W:0.4) and level of RA interference with work productivity (mean BL:5.0, C/W:1.3, on 0–10 scale) per month. Similar decreases were reported in the number of household work days missed (mean BL:8.1, C/W:1.0), days with ≥50% decreased household productivity (mean BL:10.5, C/W:1.2), RA interference with household productivity (mean BL:6.2, C/W:2.0) and days missed per month of family/social/leisure activity (mean BL:5.8, C/W:0.7). CONCLUSIONS: In the RAPID1 OLE, CZP Q2W plus MTX maintained improvements in workplace and household productivity and increased social activity participation over >4yrs.