OBJECTIVES: Foot ulceration is a major cause of disability in diabetes. The aim of this study was to estimate influence of severity of diabetic foot ulceration on HRQoL. METHODS: A survey among DFS (Diabetic Foot Syndrome) patients with active foot ulceration treated in ambulatory care was conducted. The PEDIS scale was used to classify severity of ulceration. To assess the impact of diabetic ulceration on HRQoL in DFS patients the EQ-5D-3L questionnaire was used. Utility scores were calculated based on Polish EQ-5D value set (Golicki et al.) RESULTS: Between April 2012 and May 2013 185 patients were questioned directly. 179 of them (131 males) completed the EQ-5D questionnaire and had full record on ulceration severity (the PEDIS scale). The mean age of patients was 61.9±10.6 years. Diabetes type 2 was diagnosed in 150 (83.8%) patients while diabetes type 1 in 26 (14.5%). Other type of diabetes was diagnosed in 2 persons and data on one were missing. Mean time from the diagnosis of diabetes was 18.0±11.1 years. 99 (55%) and 69 (39%) patients had grade 1 and 2 perfusion, respectively. The mean ulceration size was 6.2±13.4 cm2. 74 (41.3%), 65 (36.3%) and 40 (22.3%) patients had grade 1, 2 and 3 depth/tissue loss respectively. 84 (46.9%), 55 (30.7%) and 36 (20.1%) patients had grade 1, 2 and 3 infection, respectively. Most patients (89.4%) had loss of protective sensation (grade 2 sensation). Mean utility value in overall population was estimated at 0.618±0.320. Very week negative correlation was found between ulceration size and utility value. Despite some differences in utility value in patients with different perfusion grade no strict correlations between severity of ulceration and utility values were found. CONCLUSIONS: There is little or no strict correlation between severity of ulceration measured with the PEDIS scale and HRQoL measured with the EQ-5D.