OBJECTIVES: Abdominal adhesions are common after gynecologic surgeries, often resulting in complications such as bowel obstruction and chronic pain, which may lead to increased length of stay and more frequent readmissions. GYNECARE INTERCEED® Absorbable Adhesion Barrier is associated with fewer adhesion-related outcomes compared to surgeries without an adhesion-barrier. This analysis assesses the budget impact of GYNECARE INTERCEED®for reducing the incidence of postoperative adhesions in open surgical gynecologic procedures. METHODS: A model was constructed to evaluate the budget impact to hospitals of adopting GYNECARE INTERCEED® for women undergoing open surgical gynecologic procedures. C-section surgery, hysterectomy, myomectomy, ovarian surgery, tubal surgery, and endometriosis surgery were modeled with and without the use of GYNECARE INTERCEED®. Incremental GYNECARE INTERCEED® material costs, medical costs arising from complications, and adhesion-related readmissions were considered. GYNECARE INTERCEED®use was assumed in 50% of all procedures. Budget impact was reported over a 3-year period from a US hospital perspective (US$2013). RESULTS: Assuming 100 gynecologic surgeries of each type and an average of one GYNECARE INTERCEED® sheet per surgery, a net savings of $439,975 with GYNECARE INTERCEED® over 3 years is estimated. GYNECARE INTERCEED® use resulted in 80 fewer patient cases developing adhesions. Although the use of GYNECARE INTERCEED® added $91,500 in material costs, this was completely offset by the reduction in complication costs ($230,766 savings) and fewer adhesion-related readmissions ($300,709 savings). By preventing adhesion-related complications, GYNECARE INTERCEED®prevented over 206 additional hospital days for patients. CONCLUSIONS: This analysis represents the first economic assessment of GYNECARE INTERCEED® use in open gynecologic surgeries that incorporates the cost of the adhesion barrier, complications, and readmissions. Adoption of GYNECARE INTERCEED® absorbable adhesion barrier for appropriate gynecologic surgeries would likely result in significant savings for hospitals which would largely be driven by clinical patient benefits in terms of fewer complications and adhesion-related readmissions.