OBJECTIVES: Severe respiratory infections result in infant hospitalizations for LRTI, of which the most common cause is due to respiratory syncytial virus (RSV).  The economic impact of pediatric hospitalizations for respiratory infections is substantial; however the socioeconomic burden it has on parents and caregivers is less understood. METHODS: Data was attained from the Parent Burden Study: A prospective multinational study to determine the humanistic and economic burden of infant LRTI hospitalizations during the RSV season.  Direct healthcare resource utilization including length of hospitalization stay (LOS) and intensive care use (ICU) were obtained from medical chart reviews.   Indirect economic burden borne by parents were measured in parent surveys administered at the time infants were discharged.   Lost work productivity was assessed via the Work Productivity and Activity Impairment questionnaire, specific to caregivers of children hospitalized with respiratory illness. RESULTS: A total of 47 infants (35 term, 12 preterm), <1 year of age were included in the Parent Burden Study in Greece.  74% of infants had a confirmed diagnosis of RSV. The mean LOS was 7.50 days (range: 0.66- 40.97, 6.33 days term, 10.91 days preterm). 8.5% (2.9% term and 25% preterm) required ICU admission and 85.1% had supplemental oxygen and/or mechanical ventilation support (80% term, 100% preterm). Among fathers, the average absenteeism (time away from work) was 19.2%, presenteeism (impaired productivity while at work) was 45.6%, and overall work impairment was 55.3%.  For mothers, the average absenteeism was 47.0%, presenteeism was 35.0% and overall work impairment was 54.0%. On average, fathers reported 62.1% activity impairment and mothers reported 93.5% due to their child’s hospitalization.  51.1% of families required family or arranged childcare to assist siblings during the hospitalization. CONCLUSIONS: This study demonstrates, in addition to direct morbidity burden, infant LRTI hospitalizations have a substantial socioeconomic impact on parents and caretakers in Greece.