OBJECTIVES: To date, there has not been extensive study on the economics or established treatment guidelines in patients with non-infectious posterior uveitis (NIPU).  Current treatment is mostly topical/systemic/injection corticosteroids, though treatment is associated with significant side effects.  We undertook a secondary research analysis of MarketScan claims data to better understand the patient journey and the current treatment standard of care for NIPU patients. METHODS: We analyzed the MarketScan dataset to identify NIPU patients from a defined list of ICD-9 codes.  We then identified patients with 30 months of continuous enrollment data, 6 months prior and 24 months post initial diagnosis.  Patients were assessed for number of office visits/procedures, number of diagnostic tests, number of inpatient stays, and number and frequency of drug treatment (corticosteroids, corticosteroid injections, immunomodulators, and biologics). RESULTS: Of the 56 million lives in the claims dataset, 34,827 had an ICD-9 code consistent with NIPU. Of these unique patients, 33,386 were analyzed.  78.8% of patients came from the commercial dataset, 59% of patients were female, and the average age at diagnosis was 51.5 years.  Prior to diagnosis, 5,775 patients were treated for NIPU at an average cost of $185.43 per patient (58.0% topical/systemic corticosteroids, 22.7% corticosteroid injections, 15.7% immunomodulators, 3.7% biologics). In the 24 months post-diagnosis, the number of treated patients increased to 11,570 patients at an average cost of $249.01 per patient (45.7% topical/systemic corticosteroids, 37.4% corticosteroid injections, 16.4% immunomodulators, 3.2% biologics).  Examining each six-month period post-diagnosis, the number of treated patients decreased, but the share of treatments remained the same. CONCLUSIONS: Patients with NIPU are engaging the healthcare system and being treated for NIPU at least six months prior to an official diagnosis.  Efforts should be made to better identify patients with NIPU to ensure proper diagnosis and treatment.