OBJECTIVES: Averting 20% of new HIV infections, the country has to achieve 80% national circumcision coverage. Given the inadequacy of human resource at circumcision centers in Uganda, we conducted a study to assess the cost-effectiveness of PrePex device (none surgical) and Dorsal-slit technique (surgical) for scaling-up adult safe medical male circumcision.  METHODS: In a four weeks cost effectiveness course project during November 2012, we modeled the costs and effects of male circumcision of the 2 commonest strategies (Dorsal-slit technique as standard and PrePex device) used in Uganda. Effectiveness was defined as days of complete healing measured by costs from start of procedure to complete healing. This was the time until end of each procedure when all scores for drainage from incision, epithelialization, granulation of tissue, and edema were zero. We estimated costs and effects from previous studies in developing countries. Direct and indirect costs were included in a cost effectiveness analysis with limited government perspective. Costs for demand creation (training, patient counseling, and promotion campaigns) were excluded. One-way sensitivity analysis was done by varying costs and days of complete healing as main model parameters. Analyses were done using TreeAge Pro-2011 software. RESULTS: PrePex (none surgical) utilized $52.13 over the days to complete healing (31 days) compared to dorsal-slit (surgical) utilizing $67.8 over the days to complete healing (23 days). PrePex was less costly ($52) and with lowest adverse-events (0.98) compared to dorsal-slit technique 0.96 adverse-events costing $65.9. PrePex device was mostly not sensitive to changes in costs and days to complete healing.  CONCLUSIONS: PrePex device was cost-saving and cost effective.