OBJECTIVES: Patient reported outcomes (PRO) are becoming useful tools for collecting and generating evidence for new medical products to show improvements in health-related quality of life (HRQoL). Glaucoma is a chronic disease with high importance for patient HRQoL.  The objective of this study was to review, analyze, and understand trends in the PRO instruments used in patients with Glaucoma. METHODS: A systematic literature search for Glaucoma trials with PROs endpoints was undertaken for the databases Pubmed, Embase, Biosis, Google Scholar and Cochrane. Data was collected for the study size, interventions, year, PRO instrument and results for PROs. Analysis for conducted to identify trends in commonly used PRO instruments and categorize results as positive, neutral or negative. RESULTS: 31 studies with a total of 9819 patients were identified. In these studies there were eleven different PROs instruments were identified that were Glaucoma health perception index, Glaucoma quality of life questionnaire (Glau-QoL), Glaucoma utility index, Impact of vision impairment, Low vision quality of life questionnaire, National eye institute visual function index-19 items, National eye institute visual function index-51 items, Nursing home vision quality of life questionnaire, Quality of life and visual function questionnaire, Vision core module 1, and Vision quality of life index. The most commonly used instruments were Impact of vision impairment (used in 7 studies) and Low vision quality of life questionnaire (used in 4 studies). CONCLUSIONS: Patients with glaucoma have significant impairment in their QoL, hence collection of such data is important for new medical products. PRO instruments such as Impact of vision impairment  and Low vision quality of life questionnaire have been commonly used to generate evidence to show which therapies improve patient QoL.