OBJECTIVES: The aim of this study was to predict the cost of a delivery following assisted reproductive technologies (ART) in Poland. Moreover, the cumulated in vitrofertilization (IVF) effectiveness ratio was calculated and the costs of drugs for each of the three stimulation protocols used in IVF (long with GnRH agonist, short with GnRH antagonist and short with GnRH agonist) were estimated. METHODS: In order to calculate the IVF effectiveness, a pooled analysis of the results from European IVF monitoring reports concerning Poland from 2008 to 2010 was performed. Costs of the clinical and biotechnological parts of IVF were based on the Ministry of Health calculation. Drugs’ costs were estimated considering both dosages based on the Summaries of Products Characteristics and the retail prices. Costs were calculated based on identified costs in both the patient and payer perspectives. RESULTS: The overall birth rate per cycle was 21,70%. The probability of a delivery was 1,5 higher during fresh cycle than in frozen embryo transfer. 24,09% of embryo transfers resulted in delivery. The cost of drugs used during ovarian stimulation protocol was estimated on 6 055 PLN. The average cost per cycle was 13 565 PLN. Drugs account for 45% of this value. The average cost per birth was 42 848 PLN. CONCLUSIONS: In vitro fertilization is an expensive procedure for a patient in Poland. It is due to a limited effectiveness, usually requiring several repeats of the whole cycle of IVF with no drugs reimbursement. The ovarian stimulation is the most expensive part of the procedure. Thus, reimbursement of medication should also be established.