OBJECTIVES:   To study predictors of statin use in overweight and obese adults and consistency with current 2004 American Diabetes Association (ADA) guidelines. METHODS:   A retrospective cross-sectional analysis of National Ambulatory Medical Care Survey (NAMCS) and outpatient part of the National Hospital Ambulatory Medical Care Survey (NHAMCS) of 2005-2007 was conducted among overweight and obese adults aged 18 to 64 years. Statin prescription (received or not) was the outcome measure. Descriptive statistics and multivariate logistic regression were carried using SAS9.2 to determine predictors of receiving statin prescriptions. The multivariate model was stratified based on age: Model1¬¬ (18 to 40years) and Model2 (41 to 64years), as a significant interaction was found between diabetes and age (chunk test p= 4.3729e-8). RESULTS:   A total of 3141.387 million visits were examined, 94.176 (2.99%) with a statin prescription. Diabetics were more likely to receive a statin prescription compared to nondiabetics [Model1: Odds Ratio (O.R.) 4.12 (95%Confidence Interval (C.I.): 2.77-6.12, p<0.0001); Model2: O.R. 2.69 (95%C.I: 2.21-3.27, p <0.0001)]. Females were less likely to get statin prescription compared to males [Model1: O.R.0.52 (C.I. 0.42-0.63 p<0.0001) Model2: O.R.0.68 (C.I. 0.59-0.78 p<0.0001)]. Specialists were more likely to prescribe statin compared to generalists [Model1: O.R. 1.44 (C.I:1.31-1.84, p=0.0033); Model2: O.R. 1.61 (C.I: 1.35-1.91, p<0.0001)]. Other significant predictors included hypertension (p1=0.0037; p2 <0.0001), hyperlipidemia (p1 <0.0001; p2 <0.0001), congestive heart failure (p1=0.0044; p2 <0.0004) and counseling (p1=0.0011, p2<0.0001). Race and payment type were not significantly associated. CONCLUSIONS:   Diabetics were more likely to receive statin prescriptions compared to nondiabetics, consistent with ADA recommendations. Further research is needed to ensure achievement of target cholesterol levels in this high risk population.