OBJECTIVES: This study aimed to identify schizophrenia patients who experience favorable outcomes over a 3-year period and determine baseline predictors of favorable long-term outcomes. METHODS: We used data of a 3-year prospective, observational study of individuals treated for schizophrenia in the United States (US-SCAP; N=2327). A hierarchical cluster analysis was performed to group patients, using baseline clinical, functional, and resource utilization measures. Clinical status was based on symptom severity. Functional level reflected patient-reported productivity and occupational role functioning.  Resource utilization of psychiatric hospitalization and emergency services was systematically abstracted from medical records. A patient was classified as having a favorable long term outcome if their outcome values had the closest distance to the defined “best baseline cluster” at each point over the 3-year follow-up; stepwise logistic regression was used to determine baseline predictors. RESULTS: Of 1604 patients with sufficient data to assess 3-year outcomes, only 191 (12%) experienced favorable outcomes. Overall, 5 distinct outcome clusters were identified, ranging from best to worst. The baseline predictors of the most favorable outcomes sustained over the 3-year period included better quality of life, more daily activities, patient-reported clearer thinking, less severe positive symptoms, lower AIMS score, higher level of global functioning, being employed, not having health insurance, being female, and not having help with shopping, leisure, or social activities. CONCLUSIONS: This study identified 5 distinct clusters of patients with schizophrenia based on their baseline clinical, functional, and resource utilization factors. Current findings suggest that clinicians could make early projections of long-term outcome, thus enabling early tailored therapeutic interventions that could enhance patient’s likelihood of achieving more favorable long-term outcomes.