OBJECTIVES: The PROMIS system has undergone extensive validity testing in community populations, but has been much less studied in clinic patient populations.  We studied the time required for administration of specific PROMIS CAT and short form measures and the experience of patients using the system as expressed in responses to evaluation questions. METHODS: A convenience sample of patients receiving care for either neurological or surgical conditions, and caregivers of patients being treated for mild dementia (total N = 66) were recruited from Henry Ford Hospital outpatient clinics.  They were invited to complete a set of PROMIS CAT measures and short form surveys, and then asked to respond to a set of questions about their experience with the PROMIS system. RESULTS: No respondents failed to complete a measurement section.  Patient and caregiver ratings of the PROMIS system were very positive.  94% reported liking using the system.  98% reported that it was either “easy” or “very easy” to use.  92% found the questions easy to understand, and 93% felt that they could choose answers that reflected their feelings on most or all questions.  71% reported that the number of questions asked was “just right”, and 68% reported that they would rather answer questions on a computer than on a paper form.  The responses of individual clinical subgroups and of caregivers were quite similar to the overall pattern of responses.  On average, each PROMIS CAT module took respondents approximately 1.5 minutes to complete. CONCLUSIONS: Clinic patients, including those being treated for conditions involving possible cognitive deficits, were able to complete all PROMIS CAT or short form measures presented, and reported high levels of satisfaction with, and ease of, use of the system as a way to respond to questions on health status.