OBJECTIVES: Literature suggests that while pharmacists may be viewed as the most trusted healthcare professionals by patients, other healthcare professionals may often fail to trust them with making decisions regarding drug therapy regimens. Limited information is available regarding physicians’ therapy decisions based on pharmacist’s recommendations and the resulting patient clinical outcomes. This study aimed at finding if physicians’ therapy decisions based on pharmacist’s recommendations lead to optimal patient outcomes. METHODS: Approximately 700 employees from 2 employer groups have participated in an employer-supported pharmacist provided disease state management program. The program is provided at seven independent pharmacies across Northwest Ohio. A team of clinical pharmacists and researchers classified and created codes for specific pharmacist-provided interventions, resultant physician and/or patient responses, and consequent outcomes. Data was extracted from patient charts and entered into Microsoft Excel. Frequencies and percentages of pharmacists’ interventions, physicians’ responses and outcomes were calculated using SPSS ver. 17.0. A decision tree was created using TreeAge Pro Suite 2008 to map interventions to responses to improved/unimproved outcomes. RESULTS: A total of 446 pharmacist interventions with corresponding physician responses and patient outcomes were made.  The most frequent interventions involved drug therapy (N = 138, 31%) and formulary management (N = 105, 23.5%).  The most frequent responses by physicians were “physician acknowledged recommendation, monitoring added” (N =58, 13%) and “physician added a medication” (N = 51, 11.4%).  Physicians responded favorably to the pharmacists’ interventions 54.1% of the time.  When physicians responded favorably, an improvement was seen in 91.2% of patient outcomes compared to only 64% when physicians declined or did not respond to pharmacists’ interventions. CONCLUSIONS: Positive health outcomes result from therapy decisions made by physicians following pharmacists’ recommendations. In an effort to save costs and improve care, pharmacist-physician collaboration is essential.