OBJECTIVES: This study aimed to investigate the differences in the levels of peri-operative pain and peri-operative health-related quality of life (HRQOL) in the patients underwent orthopedic surgery. METHODS: This study is multi-center and cross sectional study based on patients survey. Total 687 patients in 36 tertiary hospitals who are supposed to be performed orthopedic surgery (arthroplasty and spinal fusion) were interviewed. Clinical, surgery profile, and quality of life data were collected. Subjects completed a face-to-face interview with trained interviewer to assess their health status, patients satisfaction, pain scale  for pain management. we obtained the quality of data through 3 interviews;  before surgery day, post op 14 days f/w (POD14) and post op 3 months f/w. we enrolled the patients during  maximum 4 months (July~ December 2009) RESULTS: Generally. the Quality of life of patients before surgery were lower than those of patients in POD 14. In average, utility weight of before surgery and POD 14 is 0.31 and 0.57. Patients who have been heard about the surgery pain from hospital staffs expected pain worse than those of who haven’t. so VAS pain scores have significant gap between expected pain and POD 1 (patients who have been heard about the surgery pain : 72.68, POD1: 65.63/patients who haven’t been :57.89, POD1: 67.25) There were significantly differences for using pre-emptive analgesics and pain management. the patients who were used for pre-emptive analgesics show the improvements compared to those who weren’t used. CONCLUSIONS: There is few study of Quality of life for real patients in korea. so it is meaningful to draw the utility weight of orthopedic surgery for patients. The findings suggest that utility weight for arthritis is lower compared to the results from national heatlh survey aiming at residents in korea (arthritis: 0.7621 from 2005 KNHANES).